Impossible to Overdose: Unlike standard sedatives, melatonin cannot stop your breathing because it doesn't target the brain's respiratory centers. It is exceptionally safe, even at high doses.

Watch the Fall Risk: For older adults, the main risk isn't toxicity; it's the potential for falls or fractures, likely due to morning drowsiness.

The "Orphan" Drug: The reason high-dose melatonin isn't a standard cancer treatment isn't a lack of science—it's a lack of profit. Because it cannot be patented, drug companies won't fund the final approval trials.