A Different Drug: At high doses (20mg+), melatonin stops being a sleep aid and starts acting as a metabolic disruptor, specifically targeting the wasteful way cancer cells burn energy.

Support is Certain, Survival is Plausible: We know for sure that melatonin helps patients feel better during chemo (less fatigue, less nerve pain). We are still waiting on definitive proof that it helps them live longer, though early trials and specific subgroups (like Stage IV lung cancer) show very promising signals.

Synergy, Not Replacement: The best data suggests melatonin works best with standard treatment, not instead of it. It may even make dangerous immune therapies safer to use.

Unconsciousness isn't Sleep: Prescription pills are excellent at sedating you, but they often sacrifice the quality of your rest to do it.

Protect the Architecture: Melatonin is one of the few options that improves sleep onset without suppressing the deep, restorative cycles (REM and Slow-Wave Sleep) that your brain actually needs to recover.

Safety Over Strength: While it may not feel as potent as a Z-drug, melatonin offers a much safer profile for long-term health, avoiding the risks of dependency and respiratory depression.