High-Dose Melatonin in Cancer Care: Flipping the Metabolic Switch
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A Different Drug: At high doses (20mg+), melatonin stops being a sleep aid and starts acting as a metabolic disruptor, specifically targeting the wasteful way cancer cells burn energy.
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Support is Certain, Survival is Plausible: We know for sure that melatonin helps patients feel better during chemo (less fatigue, less nerve pain). We are still waiting on definitive proof that it helps them live longer, though early trials and specific subgroups (like Stage IV lung cancer) show very promising signals.
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Synergy, Not Replacement: The best data suggests melatonin works best with standard treatment, not instead of it. It may even make dangerous immune therapies safer to use.



